Document Details
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Document Type |
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Thesis |
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Document Title |
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THE EFFECT OF CITRIC ACID AND LEPIDIUM SATIVUM ON LIVER AND KIDNEY FUNCTIONS OF RATS. تأثير حمض الستريك وحب الرشاد على وظائف الكبد والكلى في الجرذان |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Lepidium sativum (LS) seeds are used extensively in the folk medicine of many countries. Citric acid (CA) is commonly used as a food preservative or additive in Saudi Arabia. The aim of this research was to determine the interaction of using LS and CA combination on liver, kidney, and heart functions in rats to evaluate their safe use as antioxidants and to test the role of antioxidant effects of LS against CA hepato-renaltoxicity. This study was done on 36 male rats divided into four groups: the control group, the LS group (10g/100g of food), the CA group (5g/100g of food), and the LS plus CA group (10g LS & 5g CA/100g of food) for 6 weeks, ELISA technique was applied to measure the liver, kidney, heart enzymes also, antioxidants and free radicals levels, white blood cells (WBCs), red blood cells (RBCs) and platelets (PLTs) were counted in a hemocytometer, hemoglobin (Hb) was applied by hemoglobin assay kit (Colorimetric). The data revealed that no statistical differences were found among the food consumption, body weights and kidney weights in all groups, the liver weights for the LS and LS plus CA groups were significantly higher than control group, the heart weights for the LS group was significantly higher than other groups. Creatinine levels for LS group was significantly higher than control group, glutathione peroxidase (GPX) levels for the LS group was significantly lower than control group. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), creatinine, blood urea nitrogen (BUN), creatine kinase (CK), nitric oxide synthase (NOS), hydrogen peroxide (H2O2) and malondialdehyde (MDA) levels for the CA group were significantly higher than other groups. Lactate dehydrogenase (LDH), glutathione peroxidase (GPX), superoxide dismutase (SOD) levels for the CA group were significantly lower than other groups. White blood cells (WBCs) and platelets (PLTs) for the CA group were significantly higher than other groups. Red blood cel |
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Supervisor |
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Dr. Maha Jamel Balgoon |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1443 AH
2022 AD |
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Added Date |
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Tuesday, March 15, 2022 |
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Researchers
| ندى عوض الجهني | Al-Johani, Nada Awadh | Researcher | Master | |
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