Document Details

Document Type : Thesis 
Document Title :
ASSOCIATION BETWEEN LEVELS OF SERUM VITAMIN D AND MAJOR DEPRESSIVE DISORDER IN SAUDI POPULATION
العلاقة بين مستويات فيتامين د بمصل الدم ومرض الاكتئاب في سكان السعودية
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Depression is a common mental disorder leading to impairment in important social activity, increased medical morbidity and mortality. Vitamin D is a neurosteroid hormone that may have an important role in the development of depression, and Low Vitamin D (25-OH D) status may be associated with depression. Participants were visitors of the Psychiatry clinic at King Abdulaziz University Hospital (KAUH) who have been diagnosed with major depressive disorder (MDD). Sixty-five patients were recruited classified into two groups; the first intervention group treated with vitamin D3 (50.000 IU/week), the second patients with depression constitute the untreated group and did not receive vitamin D supplementation. Serum Vitamin D3, serotonin, leptin and ghrelin were measured using commercially available kits. The current study shown a significant difference in male subjects. Females results also shown high significant difference after vitamin D supplement. Male subjects diagnosed with moderate BDI shown significant decrease (P < 0.05) after vitamin D supplement. A high significant decrease seen in male subjects diagnosed with severe depression. Males diagnosed with extreme depression shown significant decrease in BDI score after vitamin D supplement. Females with moderate, severe and extreme depression significantly (P < 0.05) had lower BDI score after vitamin D. Serotonin was significantly increased after vitamin D supplement compared to serum levels before vitamin D supplementation in both male and female subjects. The results of the present study indicate a relationship between depressive symptoms and vitamin D deficiency and clearly shows the positive effect of vitamin D supplement on improving depression, particularly in female and overweight participants. Further studies using larger group size need to be conducted in order to confirm the results of the present study. Based on the results of this study, MDD patients with or without vitamin D deficiency may benefit from supplement with vitamin D prior to or concomitant with MDD treatment. Keywords: depression, vitamin D, mental disorders, MDD 
Supervisor : Dr. Sawsan Omar Khoja 
Thesis Type : Master Thesis 
Publishing Year : 1440 AH
2019 AD 
Co-Supervisor : Dr. Shareefa Abdullah Alghamdi 
Added Date : Thursday, August 29, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
نبيلة حشيم السلميAlSulami, Nabilah HasheemResearcherMaster 

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