Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
Synthesis and Biological Evaluation of Some New Substituted Benzoquinolines and Derived Fused Ring Systems as Anticancer and Antiviral Agents تشييد بعض البنزوكينولينات المستبدلة و بعض الحلقات المدمجة المشتقة منها و تقييم فعاليتها البيولوجية كمضادات للسرطان و مضادات للفيروسات |
|
Subject |
: |
Chemistry department |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
Cancer is a growing public problem whose estimated worldwide new incidence is about 6 million cases per year. It is the second major cause of death after cardiovascular diseases and is characterized by unregulated proliferation of cells. Therefore, such rapid spread of cancer has stimulated an unprecedented level of medicinal chemistry research activity directed towards the search for new structure leads that may be of use in designing novel antitumor drugs. On the other hand, over the past decade, there has been growing interest in acute and chronic liver diseases that are caused by an infection with hepatitis-C virus (HCV), such as hepatocellular carcinoma and liver cirrhosis. HCV is believed to act as a carcinogen by virtue of the increased risk of hepatocellular carcinoma among persistently infected patients with chronic active hepatitis. To date, the only available therapy for chronic HCV infection is the treatment with interferon-alpha (Ifn-) either alone or in combination with the nucleoside analog ribaverin, with a lot of undesirable side effects. Consequently, these facts highlight the importance and the urgent need to continue searching for new more potent, less toxic and more selective anticancer as well as anti-HCV agents. In this view, much interest has been focussed on quinoline and benzoquinoline systems since they are proved to be biological versatile compounds possessing variety of activities. Among these, wide range of chemotherapeutic activities have been ascribed to benzoquinoline derivatives including the antimicrobial, antitubercular, ntiamoebic, antiparasitic, antiviral and a variety of anticancer activities. Motivated by these facts, and in continuation in our search for new potentially active hemotherapeutic molecules, and our on-going interest in the chemistry of pyridines and quinolines, a series of benzo[h]quinoline derivatives comprising some biologically active rings such as aryl, pyrrolyl, furyl or thienyl moieties, were synthesized. This combination is suggested in an attempt to investigate the influence of such hybridization on the anticipated anticancer and/or antiviral activity, hoping to discover a new structure lead that would have a remarkable biological significance. The assigned structures were based on microanalysis and spectral data (IR, 1H-NMR, 13C-NMR and X-ray crystallography). Moreover, some of the target compounds were subjected to the Bioassay-Cell Culture laboratory, in vitro bioassays on human tumour cell lines for drug discovery unit, National Research Centre (NRC), Cairo, Egypt, to screen their anticancer activity. In the same time, twenty compounds were selected and investigated for their in vitro effect on the replication of hepatitis-C virus (HCV) in HepG2 hepatocellular carcinoma cell line infected with the virus using the reverse transcription–polymerase chain reaction (RT-PCR) technique. |
|
Supervisor |
: |
Dr. Hassan M. Faidallah |
|
Thesis Type |
: |
Master Thesis |
|
Publishing Year |
: |
1434 AH
2013 AD |
|
Co-Supervisor |
: |
Prof.Dr. Tariq R. Sobahi |
|
Added Date |
: |
Thursday, November 7, 2013 |
|
Researchers
| خالد مولاي العافية | El Avia, Khaled Moulaye | Researcher | Master | |
|
Back To Researches Page
|